
TCR-engineered NK (TCR-NK) cells
However, native NK cells often lack sufficient specificity and persistence for effective solid tumor eradication. TCR-engineered NK (TCR-NK) cells address this critical unmet need by combining NK cell anti-tumor capabilities with the exquisite antigen specificity of T-cell receptors (TCRs). This engineering allows NK cells to recognize MHC-restricted tumor antigens, expanding their targeting repertoire and enhancing precision for safer, more effective cancer immunotherapies.
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